Current status of vaccines against Diphtheria , Pertussis , Tetanus , Hepatitis B and Hib : A Review .
نویسنده
چکیده
A liquid pentavalent vaccine containing DTwP-HepB-Hib was incorporated in the Universal Immunization Program of India with the funding from Global Alliance for Vaccines and Immunization (GAVI). India introduced pentavalent vaccine in two states namely, Andhra Pradesh and Kerala in 2011. The combination vaccine offers simplification of immunization schedule, reduced cost, better acceptance and logistic benefits. However, some experts have been raising concerns regarding safety of pentavalent vaccine owing to incidents of deaths and adverse effects like hypotonic-hyporesponsive episodes following vaccine administration. Henceforth, there should be a vigilant approach towards prevention of potential adverse effects while spreading the coverage of pentavalent vaccine. The present article provides current status of potential benefits and risks associated with pentavalent vaccine against the diphtheria, pertussis, tetanus, hepatitis B and Haemophilus influenzae.
منابع مشابه
Four is better than nine. a combined diphtheria-tetanus-pertussis-hepatitis B-Haemophilus influenzae type b vaccine for routine immunization in Malaysia.
Malaysian infants would have to receive nine injections during the first few months of life in order to be protected against disease caused by hepatitis B (HBV), diphtheria, tetanus, pertussis and Haemophilus influenzae type b (Hib) if single HBV and Hib vaccines were used. We evaluated a combined DTPw-HBV/Hib vaccine administered at 1.5, 3 and 5 months after a birth dose of hepatitis B vaccine...
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Multivalent combination vaccines have reduced the number of injections and therefore improved vaccine acceptance, timeliness of administration and global coverage. The hexavalent diphtheria-tetanus-acellular pertussis-hepatitis B-inactivated poliovirus/Haemophilus influenzae type b (DTPa-HBV-IPV/Hib; Infanrix hexa™) vaccine, administered according to various schedules, is widely used for the pr...
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The combined diphtheria-tetanus-acellular pertussis-hepatitis B-poliomyelitis/Haemophilus influenza vaccine (DTPa-HBV-IPV/Hib: Infanrix™ hexa, GlaxoSmithKline Vaccines) is used for primary vaccination of infants in a range of schedules world-wide. Antibody persistence after 4 DTPa-HBV-IPV/Hib doses in the first 2 y of life has been documented, but long-term persistence data following the 3, 5, ...
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OBJECTIVE The aim of this open, multicenter, randomized trial was to evaluate the immunogenicity and reactogenicity of a candidate combined diphtheria-tetanus-acellular pertussis-hepatitis B virus-inactivated polio virus (DTaP-HBV-IPV) vaccine when given as either a mixed or as separate concomitant injections with Haemophilus influenzae type b (Hib) vaccine. STUDY DESIGN A total of 359 subjec...
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